Optimum catalyst selection over continuous and discrete process variables with a single droplet microfluidic reaction platform

Continuous-flow In-droplet Magnetic Particle Separation in a Droplet-based Microfluidic Platform

ABSTRACT We demonstrate a droplet-based microfluidic device in which in-droplet magnetic bead separation is performed in continuous-flow. Two droplets containing different solution for the magnetic bead separation are generated in pair-wise manner. Sequential fusion of droplets occurs by a geometrical structure. The magnetic beads are deflected by externally applied magnetic force from one side...

Optimum Structural Design with Discrete Variables Using League Championship Algorithm

In this paper a league championship algorithm (LCA) is developed for structural optimization where the optimization variables are of discrete type and the set of the values possibly obtained by each variable is also given. LCA is a relatively new metaheuristic algorithm inspired from sport championship process. In LCA, each individual can choose to approach to or retreat from other individuals ...

Numerical Study of Droplet Generation Process in a Microfluidic Flow Focusing

Microfluidic flow focusing devices have been utilized for droplet generation on account of its superior control over droplet size. Droplet based microfluidics addressed many scientific issues by providing a novel technological platform for applications such as biology, pharmaceutical industry, biomedical studies and drug delivery. This study numerically investigated the droplet generation proce...

Droplet Microfluidic Platform for Cell Electrofusion

A Droplet Microfluidic Platform for Automating Genetic Engineering.

We present a water-in-oil droplet microfluidic platform for transformation, culture and expression of recombinant proteins in multiple host organisms including bacteria, yeast and fungi. The platform consists of a hybrid digital microfluidic/channel-based droplet chip with integrated temperature control to allow complete automation and integration of plasmid addition, heat-shock transformation,...